HPV of the Upper Airway

Human papillomavirus (HPV) is a major driver of disease in the upper airway, contributing to conditions ranging from recurrent respiratory papillomatosis to oropharyngeal cancer. These diseases can have substantial effects on quality of life and often require repeated interventions, prolonged surveillance, and significant healthcare resources.

Our research focuses on understanding the epidemiology, clinical impact, and healthcare burden of HPV-related disease, while evaluating strategies to improve outcomes and optimize resource utilization. Ongoing work includes a multinational cohort study and transmission model examining the burden of HPV-related disease in the upper airway and its impact on healthcare utilization. We are also evaluating the cost-effectiveness of treatment strategies for HPV-associated oropharyngeal cancer, including comparisons of transoral robotic surgery (TORS) and radiotherapy, as well as studies quantifying the economic burden of oropharyngeal cancer on patients and healthcare systems. Together, these projects aim to generate evidence that informs prevention, treatment, and long-term management of HPV-associated disease.